| GANON | Main antagonist of "The Legend of Zelda" |
| MADDOG | Nickname of Buford Tannen, the main antagonist of the film Back to the Future Part III (3,3) |
| SHYLOCK | Main antagonist of The Merchant of Venice |
| ARES | Main antagonist of the video game God of War |
| NEOCORTEX | Doctor ____ is the main antagonist of the Crash Bandicoot video games |
| BURNS | Mr ___, the main antagonist of The Simpsons (5) |
| VOLDEMORT | Main antagonist of the Harry Potter series who is also known as The Dark Lord |
| CHUCKY | Main antagonist of the 'Child's Play' series of horror films (6) |
| SHEREKHAN | Main antagonist of The Jungle Book |
| FREDDYKRUEGER | Main antagonist of the A Nightmare on Elm Street films |
| APOLLOCREED | Main antagonist of the first two "Rocky" movies |
| ROSA | Main antagonist of the 1963 James Bond film From Russia with Love, played by Lotte Lenya (4) |
| KLEBB | Main antagonist of the 1963 James Bond film From Russia with Love, played by Lotte Lenya (5) |
| IMMORTANJOE | Main antagonist of the 2015 film Mad Max: Fury Road, played by Hugh KeaysByrne (8,3) |
| LINK | Protagonist of The Legend of Zelda: Breath of the Wild |
| MINIGAME | Lesser component of "The Legend of Zelda," say |
| MARIO | Video game plumber whose portrait appears in this section of "The Legend of Zelda" series |
| IRVING | With pen names including Diedrich Knickerbocker and Geoffrey Crayon, the author of The Legend of Sleepy Hollow and Rip Van Winkle (6) |
| ICHABOD | Hero of The Legend of Sleepy Hollow, ... Crane (7) |
| ALEXANDER | _ Skarsgard, star of The Legend Of Tarzan (9) |
