Across and Down

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There are 5 clues with the answer 'NEOCORTEX'
# CLUE
1.
center of conscious thought
2.
Highly developed region
3.
Company investing in exploitation of next ore showing a bit of brain (9)
4.
One bad apple overwhelms Irish public service broadcaster, I think?
5.
Doctor ____ is the main antagonist of the Crash Bandicoot video games