| TAFFY | ____ Thomas MBE, the UK's first Laureate for Storytelling |
| DJFRESH | English music producer, born Daniel Stein, responsible for the UK's first dubstep number one, Louder, featuring Sian Evans, and first drum and bass number one, Hot Right Now, featuring Rita Ora |
| JOHNELLIOTBURNS | ____, the UK's first working-class cabinet minister (in 1905) later coined the phrase "The Thames is liquid history" |
| GOWER | Peninsula in Wales including the Mumbles and Rhossili Bay that was designated as the UK's first Area of Outstanding Natural Beauty in 1956 (5) |
| ATTLEE | The UK's first Deputy Prime Minister, 1942-45 |
| ERNIEWISE | Comedian once thought to have made the UK's first mobile phone call |
| ROTTENROW | Avenue of Hyde Park, the UK's first artificially lit highway |
| STEVENAGE | Located in Hertfordshire, the UK's first new town (9) |
| SMILE | The UK's first fully digital bank, created in 1999 (5) |
| OILWELL | Hardstoft No 1, near Tibshelf in Derbyshire was the UK's first inland ____ |
| PIPEX | The UK's first internet service provider (launched in 1990) (5) |
| SPACEPORT | Sutherland is to have the UK's first one (9) |
| SLOUGH | Site of the UK's first trading estate (6) |
| ALPEN | Brand of the UK's first Swiss muesli in 1971 |
| THATCHER | Surname of the UK's first woman Prime Minister (8) |
| BORSTAL | Suburb of Rochester, Kent, which housed the UK's first juvenile prison |
| BECKETT | Margaret, politician who was the UK's first female foreign secretary (7) |
| THEDAMNED | Band who released the UK's first punk single, in 1976 |
| NIELSBOHR | 1922 Nobel physics laureate, for work on “the structure of atoms and [...] the radiation emanating from them” |
| FRANCIS | Nobel laureate for his work on the structure of DNA, ... Crick |
