| LYN | ___ St. James, first woman to be named the Indy 500 Rookie of the Year, 1992 |
| RYAN | Seacrest who's been named the next host of Wheel of Fortune |
| CROSS | 1952-55 F1 driver; 1952 Indianapolis 500 Rookie of the Year (3,5) |
| ART | 1952-55 F1 driver; 1952 Indianapolis 500 Rookie of the Year (3,5) |
| ENDOFTHEROAD | Billboard's #1 song of the year, 1992 |
| ALOMAR | Jay of the year, 1992 |
| CLAIRETAYLOR | The first woman to be named one of the Wisden Cricketers' Almanack's Cricketers of the Year |
| STTHERESA | First woman to be named Dr. of the Catholic Church |
| STTERESA | First woman to be named Doctor of the Church, briefly |
| TINAFEY | "You can't be that kid standing at the top of the waterslide, overthinking it. You have to go down the chute." She was the first woman to be head writer on Saturday Night Live. |
| CORI | First woman to be awarded the Nobel Prize in Physiology or Medicine for her role in the discovery of the course of the catalytic conversion of glycogen (surname only) |
| JANETRENO | First woman to be named Attorney General |
| OCONNOR | First woman to be appointed to the Supreme Court of the United States, Sandra Day ... (1'6) |
| KNIGHT | Painter Dame Laura who, in 1936, broke tradition when she became the first woman to be elected to full membership of the Royal Academy (6) |
| HALLOWES | Secret agent tortured by the Gestapo who became the first woman to be awarded the George Cross (8) |
| LIBBY | The first woman to be a bishop in the Church of England (5,4) |
| FLORENCE | British hospital reformer who was the first woman to be awarded the Order of Merit (8,11) |
| NIGHTINGALE | British hospital reformer who was the first woman to be awarded the Order of Merit (8,11) |
| AFFLUENZA | Critique of consumerism by the psychologist Oliver James first published in 2007 (9) |
| SMALL | James ....., first South African to be sent off in a rugby union international (5) |
