| SHERE | ___ Khan, antagonist in "The Jungle Book" |
| TEJA | "___ main hoon. Mark idhar hai." Fill in the blanks with the name of one of the antagonists in the movie Andaz Apna Apna, played by Paresh Rawal |
| BIFF | Forename of the main antagonist in the Back to the Future films (4) |
| LER | The Once-___ (antagonist in "The Lorax") |
| BOWSER | The main antagonist in the Super Mario video games (6) |
| MYERS | Michael who's the antagonist in the Halloween movies |
| HAMAN | Bad actor, an antagonist in the Book of Esther (5) |
| VOORHEES | Jason _, antagonist in the Friday the 13th horror franchise (8) |
| SHO | ___'nuff (antagonist in the 1985 film "The Last Dragon") |
| IAGO | The main antagonist in the Shakespeare play Othello (4) |
| TROLL | Antagonist in the fairy tale "The Three Billy Goats Gruff' (5) |
| CESAREBORGIA | Italian cardinal and mercenary leader, the main antagonist in the video game Assassin's Creed: Brotherhood |
| MONICA | Bellucci, Italian actress who played the main antagonist in the 2024 film Beetlejuice Beetlejuice (6) |
| DOUGRAYSCOTT | Actor who played the main antagonist in the 2000 action spy film Mission: Impossible II (7,5) |
| HOPPER | Dennis -, actor who portrayed the antagonist in the film 'Speed' (1994) (6) |
| STINGRAY | Secondary antagonist in the 2023 film Aquaman And The Lost Kingdom, played by Jani Zhao (8) |
| SNOW | Coriolanus ___, ruler of Panem and the main antagonist in The Hunger Games series of novels |
| ROTH | Hyman ___, main antagonist in "The Godfather Part II" |
| JUNO | Antagonist in the "Aeneid" |
| FROLLO | Cleric antagonist in "The Hunchback of Notre Dame" |
