| PA | Who is the only woman to have been a Republican candidate for US vice president? (5) |
| CURIE | Co-discoverer with her husband of radium and polonium and only woman to have been awarded a Nobel Prize twice (5) |
| BIDEN | Who is the US vice-president? (5) |
| ROGERAILES | Media exec for the cable channel that is hosting a Republican candidates debate on August 6, 2015 |
| MCCAIN | John - - -, Republican candidate for US president |
| EDWARDS | John ?, Democratic nominee for US vice president in 2004 |
| ANTIMONARCHICAL | Committing no criminal act. Ah, to be a republican! (15) |
| ROYALIST | Tory Lisa turned out not to be a republican (8) |
| YENTL | 1983 movie for which Barbra Streisand became the only woman to win a Golden Globe for Best Director |
| PALIN | Sarah ___, Republican candidate for vice president of the US in 2008 (5) |
| MARIECURIE | The first woman to win a Nobel Prize, and the only woman to have won it twice (for Physics in 1903 and Chemistry in 1911) (5,5) |
| DOMEE | Shi who was the first woman to have the sole director's credit on a Pixar feature, for "Turning Red" |
| IRENE | ____ Adler, the only woman to best Sherlock Holmes |
| VINCI | Leonardo da ___ Italian painter of Mona Lisa who is also known to have been a polymath of the Renaissance |
| DANICA | Patrick who is the only woman to have won an IndyCar race |
| ERROR | The lesser rorqual shows there to have been a mistake (5) |
| DEATH | The end shows there to have been a shortage, right out (5) |
| QUEEN | The only woman on the board? (5) |
| BOOTHROYD | The only woman to have served as speaker of the House of Commons (9) |
| EVADE | Dodge first woman to have a key (5) |
