| NOONE | Who is "too small to make a difference," per a Greta Thunberg book title |
| ISTOO | Greta Thunberg book "No One ___ Small to Make a Difference" |
| ARE | "If you think you ___ too small to make a difference, try sleeping with a mosquito" (Dalai Lama) |
| DURAG | "Anyone who has ever worn a ___ spells it '___,'" per a 2018 New York Times article |
| EDSEL | "The motor industry's Titanic," per a 1994 book |
| UNDERAGE | Do too little to make cadet run off (8) |
| HOTTO | "Too ___ Handle" (Netflix reality show) |
| SOSAD | Words after "too bad" |
| NUISANCE | Is apparent in a shade of difference, and it's a bind (8) |
| TIPTHESCALES | It could make the difference and topple Libra (3,3,6) |
| CUTNOICE | Make no difference and do what former diamond workers do? |
| ASL | In which four raised fingers and a curved thumb is "B," in brief |
| ART | "A jealous mistress," per Emerson |
| GROWINGUP | "Losing some illusions ... perhaps to acquire others," per Virginia Woolf |
| THAI | Language in which "thank you" is "khaawp khun" |
| SOID | "___ say..." ("My guess is...") |
| TRACE | Ground plan of a fortification; an amount of rain too small to be measured; the sum of the diagonal elements of a square matrix; or, a line marked by a recording instrument (5) |
| EMO | "Music's most maligned genre," per critic Tom Connick |
| HATRED | The "vice of narrow souls," per Balzac |
| DATA | "The world's most valuable resource," per The Economist |
