| DRAGANDDROP | What can you do with mouse, a pest, and very little? |
| CATCHIT | Mouser given official note on what to do with mouse! (5,2) |
| OPIE | TV kid who said, "Pa, just what can you do with a grown woman?" |
| SLEEPONIT | What can you do with a bed? Defer your decision |
| PERMIT | What can you do with straight hair? Pass (6) |
| ITS | "___ what ___" (shortened but unpopular version of "what can you do?") |
| UTAHSAINTS | English electronic music duo whose top ten hits include What Can You Do for Me and Something Good (4,6) |
| WELP | Slangy lead-in to "What can you do?" |
| SKILLSET | Sulphur is fatal to life on remote planet - what can you do? |
| ENTERTAIN | Please, what can you do in Victoria? One right to leave (9) |
| SIGH | "Oh, well, what can you do..." |
| CESTLAVIE | "Eh, what can you do," in Anjou |
| ALAS | "Welp, what can you do?" |
| THATSLIFE | "What can you do!" |
| SLUGGARD | Lazy fellow, a pest, and where, mostly (8) |
| SPITE | I meet a pest and this creates lasting ill-will (5) |
| RIDDLE | A silly question with a funny answer, like this one: What can you break without even touching it? (Answer: A promise) |
| MISEENSCENE | A style of direction in the cinema which uses a relatively static camera with subjects in full shot and very little cutting (4,2,5) |
| NEUTRINO | Subatomic particle with zero charge and very little mass (8) |
| COOKIE | "If You Give a Mouse a __" (picture book) |
