| LEDTO | Was the cause of |
| PRIAM | Last king of Troy, whose son was the cause of the Trojan War (5) |
| HELEN | Beauty who was the cause of the Trojan war |
| UNDERLAY | Was the cause of something being initially floored (8) |
| ASPIC | Savoury jelly was the cause of Cleopatra's death, I see (5) |
| OPIUM | What substance was the cause of war between Britain and China 1839-1842? (5) |
| TREASON | After the start of the trial, argue the cause of crime |
| UNIMAGINABLE | 'Proper punctuation is both the sign and the cause of clear thinking. If it goes, the degree of intellectual impoverishment we face is ___.' Lynne Truss |
| LABOUR | "The cause of ______ is the cause of Ireland", James Connolly. (6) |
| EDMUNDBURKE | 18th-century British Whig statesman regarded as the philosophical founder of modern conservatism; Thoughts on the Cause of the Present Discontents (1770) |
| HIV | Francoise Barre-Sinoussi, a French virologist and winner of the Nobel Prize in Physiology or Medicine in 2008, did the fundamental work in identifying ___ as the cause of AIDS |
| PROPAGANDA | The organised dissemination of information to assist or damage the cause of a government or movement (10) |
| ARSENALS | The contents of these magazines can be the cause of disturbing reports (8) |
| BEER | "The cause of and the solution to all of life's problems," per Homer Simpson |
| FOUNDFAULT | Located the cause of the trouble and was critical |
| DEFUSE | Fed up; work to get rid of the cause of tension |
| BIOPSY | A medical examination of tissue from a living body under a microscope to determine the cause of a disease (6) |
| CLOTHESPEGS | They are the cause of hangups on the line (7,4) |
| OLDAGE | The cause of most deaths in the Neolithic, say? (3,3) |
| EPIDEMIC | Bad pie taken by new medic to be the cause of the disease (8) |
