| LAISABELA | Village in the Dominican Republic, founded by Christopher Columbus in 1493, considered the first formal European settlement in the New World |
| ANTIGUA | Island named by Columbus in 1493 |
| STKITTS | Leeward Island visited by Columbus in 1493 |
| NINA | La ---, one of the three Spanish ships used by Christopher Columbus in his first voyage to the West Indies in 1492 (4) |
| SANTO | The remains of Christopher Columbus are believed to lie in the Cathedral of Santa Maria la Menor in the Dominican Republic's capital, ... Domingo |
| INDIES | Named by Christopher Columbus in 1492 when he mistakenly believed he was landing in Asia, The Caribbean is also known as the West ... |
| SANTAMARIA | Largest of the three ships used by Christopher Columbus in his first voyage (5,5) |
| VENEZUELA | The coast of what would become this South American nation was sighted by Christopher Columbus in 149 |
| CARAVEL | Type of boat such as the Pinta used by Christopher Columbus in 1492 (7) |
| PARACELSUS | German-Swiss physician born in 1493 who established the role of chemistry in medicine (10) |
| ALHORFORD | 5-time NBA All-Star center born in the Dominican Republic: 2 wds. |
| MERENGUE | Type of lively dance music originating in the Dominican Republic (8) |
| ALKAHEST | Hypothetical universal solvent sought by the alchemists, originating in the writings of the Swiss physician Paracelsus (1493-1541) (8) |
| DIA | A day in the Dominican Republic |
| ESTE | Direction in the Dominican Republic |
| LICIT | In the Dominican Republic, Italian vermouth is legal (5) |
| MOCA | Provincial capital in the Dominican Republic |
| BACHATA | Romantic music genre originating in the Dominican Republic |
| DIAS | Days in the Dominican Republic |
| PUNTA | ___ Cana (resort town in the Dominican Republic) |
