| ZOESALDANA | US actress of the Star Trek, Avatar and MCU franchises (3,7) |
| GUARDIANSOF | With 52-Across, MCU franchise in which 23-Across plays Nebula: 2 wds. |
| MUNN | US actress of The Newsroom and The Predator, Olivia - (4) |
| BILSON | US actress of The OC and Hart of Dixie, Rachel - (6) |
| CLARABOW | US actress of the silent film and early 'talkies' era known as the original 'It Girl' (1905-65) (5,3) |
| NOYES | US actress of The Deuce and Quantico, Amber Skye - (5) |
| LILLIANGISH | US actress of the silent era, associated with films of DW Griffith |
| SALDANA | US actress of Avatar and Colombiana, Zoe - (7) |
| KLINGONS | Alien race of the Star Trek franchise native to the planet Qo'noS (8) |
| ANTON | _ Yelchin, late star of the Star Trek reboots (5) |
| SPACE | Word at the beginning of the "Star Trek" opening sequence |
| ZOE | Saldana of "Avatar" and "Guardians of the Galaxy" |
| GIOVANNI | _ Ribisi, star of the films Avatar and Saving Private Ryan (8) |
| TNG | One of the 'Star Trek' series, to fans |
| CHO | Actor John of the "Star Trek" movies |
| PICARD | Surname of the Star Trek captain portrayed by Patrick Stewart |
| BONES | Nickname of the Star Trek character Leonard McCoy |
| HAS | Third-to-last word of the "Star Trek" opening speech |
| ADAMS | US actress of Arrival and Man of Steel, Amy -(5) |
| LINDA | US actress of Bloodline and Freaks and Geeks, - Cardellini (5) |
