| TCELL | Type of lymphocyte that matures in the thymus gland and plays an important role in the immune response (1,4) |
| BCELL | Lymphocyte that matures in the bone marrow |
| SWEETBREAD | The pancreas or the thymus gland of an animal, used for food (10) |
| ROSE | Flower that plays an important role in the story of 14A (4) |
| ENDORPHIN | Opiate-like peptide hormone such as enkephalin, produced by the pituitary gland and the central nervous system to block pain sensation (9) |
| THYMUS | Gland and herb reduction unpleasantly served for starters (6) |
| MASQUERADEPARTY | Event in which midnight plays an important role |
| FEATURES | Plays an important role (8) |
| TNOTE | Govt. issue that matures in 1-10 years |
| TBILL | Security that matures in a year or less, briefly |
| TANCRED | Norman leader in the First Crusade who played an important role in the capture of Jerusalem (1078-1112). |
| SMUTS | Jan ___, South African statesman who played an important role in the establishment of the League of Nations (5) |
| HURRICANE | Single-seater fighter plane that played an important role in the Battle of Britain (9) |
| SHEEP | Farm animal, Mallorca's White variety has played an important role in the island's commercial activity for many years, and the Red, which originally came from North Africa, is highly prized for its wo |
| SNAKE | Creature which played an important role in religious and cultural life in ancient Greece and Egypt (5) |
| RENIN | What enzyme secreted by the kidneys plays an important part in the maintenance of blood pressure? (5) |
| ENDOCRINOLOGIST | An expert in diagnosing and treating disorders of the glands and organs that make hormones (15) |
| RAGS | During World War I, this French stray dog was adopted by an American serviceman to be part of his unit. He played an important role as a message carrier, running notes between the rear headquarters an |
| ACT | Play an important role? |
| MAINSTAY | Something that plays the most important role in a particular group (8) |
