| VINCI | Tuscan commune where the polymath who painted Salvator Mundi was born (5) |
| LEONARDO | First name of the polymath who created Salvator Mundi (8) |
| SIENA | Tuscan commune |
| HOOKE | English polymath who formulated the law of elasticity, developed the balance spring, built the first Gregorian telescope and coined the word "cell"(5) |
| YOUNG | Polymath who contributed towards the wave theory of light (5) |
| ISAAC | English polymath who formulated his theory of gravity whilst watching apples fall, _ Newton (5) |
| ROMAN | A medieval tale of chivalry; a novel; a citizen of ancient "Caput Mundi" or of the "Eternal City"; or, ordinary type, as opposed to italic (5) |
| OPACI | ... and of her shady realm, ____ ... mundi, Ov. Met. 5.507 |
| DAVINCI | This answer means "from Vinci" in Italian. It is attached to the name of a certain Italian painter, sculptor, architect, and engineer to whom the painting Salvator Mundi has been attributed. That pain |
| ORB | Crystal object featured in Leonardo da Vinci's "Salvator Mundi," the most expensive painting ever sold |
| CHARLES | Given name of the polymath considered the father of the computer who invented the difference engine and worked with Ada Lovelace on the later analytical engine (7) |
| ROBERT | Forename of either the polymath discoverer of the law of elasticity, the inventor of the Bunsen burner or the Royal Society co-founder regarded as the first modern chemist (6) |
| COATI | - -mundi |
| CHRISTIES | Auction house that sold Da Vinci's Salvator Mundi for $450.3 m in 2017 (9) |
| THOMASYOUNG | Polymath who helped establish the wave theory of light and decipher the Rosetta Stone (6,5) |
| AVICENNA | Name by which the Persian polymath who wrote The Book of Healing and The Canon of Medicine is known (8) |
| ROSA | Salvator -; Italian Baroque artist who painted Allegory of Fortune and Landscape with Tobias and the Angel (4) |
| LAPLACE | French polymath who came close to postulating the concept of the black hole with what he called corps obscur, or "dark body" (7) |
| STRABO | Hellenistic polymath who wrote the 17-book encyclopedia Geographica (6) |
| LEIBNIZ | German polymath who rivalled Newton in the development of calculus |