| YAZOO | Tributary of the Mississippi |
| MISSOURI | Biggest tributary of the Mississippi (8) |
| RED | Tributary of the Mississippi, ___ River |
| OHIO | Tributary of the Mississippi River (4) |
| ARKANSAS | Major tributary of the Mississippi |
| RIORIVER | Tributary of the Mississippi in Texas and Louisiana (3,5) |
| REDRIVER | Tributary of the Mississippi in Texas and Louisiana (3,5) |
| DES | Iowa's capital named after a tributary of the Mississippi River, ... Moines |
| HOOVERDATUM | "The first occupant of the White House to be born west of the Mississippi River," e.g.? |
| SPACENEEDLE | Iconic observational tower of Seattle which which was the tallest building west of the Mississippi River at the time it was built: 2 wds. |
| LEWIS | Meriwether, US explorer who, with Clark, led an expedition to explore the lands to the west of the Mississippi in the early 19c (5) |
| RIVERRAT | 1984 Tommy Lee Jones film set on the banks of the Mississippi, with "The" |
| CHEROKEE | The vast majority of this native North American people were forced to move to a reservation west of the Mississippi in 1838 (8) |
| ITASCA | Lake at the source of the Mississippi |
| LSU | Sch. on the banks of the Mississippi |
| DELTA | Large US airline named for the southern region of the Mississippi River |
| MIND | View of both sides of the Mississippi Sound (4) |
| DESOTO | Explorer who died on the banks of the Mississippi |
| NCAR | Site of Mt. Mitchell, highest U.S. point east of the Mississippi |
| STLOUIS | US city at the confluence of the Mississippi and Missouri rivers |
