| STEVENAGE | Town in Hertfordshire which was designated the UK's first New Town in 1946 (9) |
| JALAPENO | What was designated the "State Pepper of Texas" in 1995? (8) |
| SPACEPORT | Sutherland is to have the UK's first one (9) |
| THEDAMNED | Band who released the UK's first punk single, in 1976 |
| ADDINGTON | Prime minister from 1801-04 later titled 1st Viscount Sidmouth who delivered the UK's first budget speech (9) |
| ERNIEWISE | Comedian once thought to have made the UK's first mobile phone call |
| ROTTENROW | Avenue of Hyde Park, the UK's first artificially lit highway |
| CHINAWARE | Crocks feature one in town in Hertfordshire (9) |
| HEMPSTEAD | Town in Hertfordshire west of St Albans (5,9) |
| NAPLES | The Castel Nuovo was founded in 1279 by Charles I in this city, and it's among the notable structures in this city's historic centre, which was designated a UNESCO World Heritage site in 1995. (6) |
| BOURGES | The Gothic cathedral of Saint-Etienne, which was designated a UNESCO World Heritage site in 1992, dominates this French city. It was constructed in 50 years, beginning at the end of the 12th century, |
| EPSOM | Surrey town in which the UK's first automatic telephone exchange was installed in 1912 (5) |
| GOWER | Peninsula in Wales including the Mumbles and Rhossili Bay that was designated as the UK's first Area of Outstanding Natural Beauty in 1956 (5) |
| REACTOR | The UK's first was opened at Calder Hall in Cumbria in 1956 (7) |
| LETCHWORTH | Town in Hertfordshire founded in 1903 as the first garden city in England (10) |
| HEMEL | & 5D New town in Hertfordshire on the chalk foothills of the Chilterns (5,9) |
| DARESSALAAM | Former capital of Tanzania replaced by Dodoma, which was designated as such in 1974 (3,2,6) |
| JOHNELLIOTBURNS | ____, the UK's first working-class cabinet minister (in 1905) later coined the phrase "The Thames is liquid history" |
| OILWELL | Hardstoft No 1, near Tibshelf in Derbyshire was the UK's first inland ____ |
| MANTUA | Small city in northern Italy (pop about 50,000), designated the Italian City of Culture in 2017 (6) |
