| MODIFY | To alter or change in structure or intent (6) |
| LESION | Injury or change in an organ or tissue tending to result in impairment or loss of function |
| IRISHSTEW | Fare rises with changes in structure |
| METAMORPHIC | Rock changed in structure or composition by natural agencies such as heat and pressure (11) |
| LOOSE | Not compact or dense in structure or arrangement (5) |
| INTERVENE | To take part in something so as to alter or prevent a course of events (9) |
| VARY | Cause to be different; to alter or modify (4) |
| COOK | (Slang) to alter or falsify (4) |
| REACTIONS | Goosebumps, hiccups, knee-jerk reflexes, pins and needles, yawns or other responses to stimuli; transformations within atomic nuclei; or, processes or changes in which chemicals form new compounds (9) |
| SYMPTOMS | Sensations or changes in bodily functions associated with a particular disease (8) |
| TURNOVERS | New TV nurse or changes in staff (9) |
| MALICE | Ill will or intent to do evil |
| HACKER | He breaks into computer systems to steal, alter or destroy information. (6) |
| TAMPER | Alter or falsify, evidence perhaps (6) |
| ADJUST | Alter or move slightly (6) |
| INDIGO | Shade dog in structure beneath beam (6) |
| ANOMIE | State or condition originally described by Emile Durkheim, characterised by hopelessness in society as a result of lack of structure or an absence of norms (6) |
| CASTLE | From the Latin for "little fort", a structure or complex of buildings fortified against attack, of which the central donjon or keep in the Middle Ages was its most essential part (6) |
| CHANGE | Alter or vary (6) |
| FRAMES | Word for the structures or skeletons of human bodies; or, the rigid surrounds of doors, lenses, paintings or windowpanes (6) |
