| INABIGWAY | To a significant extent (2,1,3,3) |
| CONSIDERABLY | To a significant extent |
| NOTICEABLY | Fighting a by-election, Conservative finally lost to a significant extent (10) |
| MATERIALLY | Friends accept religious instruction to a significant extent |
| GREATLY | To a significant extent (7) |
| MILESTONE | Word for a waymarker/guidepost indicating distances to the nearest town or village, also used figuratively to describe a significant life event (9) |
| VOLTEFACE | Left out, admitted to very old "great" it's a significant change in position (5-4) |
| TELLINGLY | I"ll gently move in a significant manner (9) |
| LANDSLIDE | Catches lake fish for a significant win in contest |
| SEACHANGE | Name for a significant transformation (from The Tempest) |
| BOMBASTIC | Grandiose failure receiving a significant portion of blame (9) |
| TOSPEAKOF | Of a significant nature (2,5,2) |
| PRESCHOOL | Nursery periodically purged a significant number of fish |
| IMPACTFUL | Having a significant effect |
| EIGHTIETH | Destroy the nameless thing that is a significant anniversary (9) |
| CENTENARY | The 100th anniversary of a significant event; or, its celebration (9) |
| SLINGSHOT | Weapon that played a significant part in Balearic history; Mallorca's skilled users of the device were highly sought after by ancient Greeks and Romans, and competitions are still held in the islands |
| KEY | Vulnerable thing to give a significant other to your apartment or heart |
| CONCORDANCE | A list showing every use of a significant word in a text, especially the Bible |
| ANOINT | Select to fill a significant role, especially in a religious context |
