| ANDROMEDASTRAIN | Titular disease of Crichton's best selling novel |
| LECARRE | 86-year-old author of a number of best-selling novels over the past 56 years, most recently A Legacy of Spies (2,5) |
| ESAU | Philip Kerr's best-selling novel of '96 |
| TARA | Image on the cover of 1936's best-selling novel |
| LOLITA | 1962 Kubrick adaptation of a best-selling novel |
| STOWE | Author of the 19th century's best-selling novel |
| THEGOBLET | Film based on the best-selling novel by J.K. Rowling, Harry Potter and ___ of Fire (3,6) |
| BEES | The Secret Life of -; best-selling novel by Sue Monk Kidd (4) |
| THEREWERENONE | And Then ___ Agatha Christie's best selling novel published in 1939 about a group of strangers who arrive as guests on a private island: 3 wds. |
| OCEAN | Film based on a best-selling novel, The Deep End of the _ (5) |
| HARRIETBEECHERSTOWE | Author of the century's best-selling novel (published 3/20/1852) |
| THECRUELSEA | Nicholas Monsarrat's best-selling novel of the WWII Atlantic (3,5,3) |
| SEA | Nicholas Monsarrat's best-selling novel of the WWII Atlantic, The Cruel ... |
| QUOVADIS | Best-selling novel set in ancient Rome |
| THEFIRM | Best-selling novel featuring lawyer Mitch McDeere |
| EYELESSINGAZA | Aldous Huxley's best-selling novel about the socialite Anthony Beavis |
| AMANINFULL | Best-selling novel by Tom Wolfe, published in 1998 |
| ROADS | Best-selling novel and Alex Pettyfer film, Back ... (5) |
| COMA | 1977 best-selling novel by physician/author Robin Cook |
| POISONWOOD | The ___ Bible, best-selling novel by Barbara Kingsolver (10) |
