| CAPEHORN | Tip of the South American continent (4,4) |
| ANDES | Mountains running the length of the South American continent |
| TUCOTUCO | Any rat-like burrowing rodent of the South American genus Ctenomys, related to the degus (4-4) |
| SANTIAGO | Capital of the South American country once led by Augusto Pinochet |
| REDSKINS | Natives of American continent - or what the 'palefaces' called them? (8) |
| VESPUCCI | Italian explorer (surname) after whom the American continent was named (8) |
| ANTEATER | Any of the four extant mammal species comprising the South American suborder Vermilingua ('worm tongue') (8) |
| COLOMBIA | The CIA bloom all over the South American state |
| ELDORADO | City of gold once believed to exist in the South American rainforest |
| MAGELLAN | Strait of ........ , sea route between Tierra del Fuego and the South American mainland (8) |
| ROCKCAVY | The South American rodent Kerodon rupestris |
| PAMPERO | Strong polar wind of the South American pampas, typically blowing south or southwest during the winter (7) |
| SURINAM | Former spelling of the South American republic of which the capital is Paramaribo (7) |
| LAKEMARACAIBO | Body of water in north-west Venezuela that is the centre of the South American oil industry (4,9) |
| LUNGFISH | Elongated freshwater air-breathing creature such as the South American ___ or West African ___ (8) |
| ESTANCIA | East uncovers a new spy group in the South American dwelling (8) |
| MOSQUITO | Doctor, smitten initially with the South American capital, is a bloodsucker (8) |
| FROG | The dreaded arrow poison of the South American natives (now being investigated as a possible replace |
| YERBAMATE | Stimulating milky beverage made from the dried leaves of the South American tree Ilex paraguariensis |
| MARACAIBO | Lake --- in N.W. Venezuela is the centre of the South American oil industry (9) |
