| TRESCO | The second-largest of the Isles of Scilly |
| STMARYS | The largest of the Isles of Scilly |
| ANISLANDPARISH | British television documentary covering the lives of residents of the Church of England parish of the Isles of Scilly (2,6,6) |
| STAGNES | Virgin martyr and one of the Isles of Scilly (2,5) |
| LANDSEND | 28 miles from the Isles of Scilly, the most-westerly point of Cornwall and England which is the start point of an iconic 874-mile bike ride to John o'Groats (5,3) |
| PUFFIN | Auk inhabiting locations including the Faroe Islands, the Isles of Scilly, Skokholm off the Pembrokeshire coast and its neighbouring Skomer (6) |
| LYONESSE | Tract of land fabled to stretch between Land's End and the Isles of Scilly (8) |
| ROCK | Lighthouse off the Isles of Scilly established in 1858 (6,4) |
| BISHOP | Lighthouse off the Isles of Scilly established in 1858 (6,4) |
| BISHOPROCK | Lighthouse off the Isles of Scilly established in 1858 |
| DUCHY | - of Cornwall; private estate established by Edward III in 1337 that includes most of the Isles of S |
| LNER | Abbreviated form of the second-largest of the "Big Four" railway companies created by the Railways Act of 1921 |
| IDLES | Is ticking over with drum-head in the Isles of France (5) |
| THEBE | The second largest of the inner satellites of Jupiter (5) |
| HURON | Lake ---, the second largest of the Great Lakes of North America (5) |
| ULVA | "Wolf Island" off the west coast of Mull that inspired Sir Walter Scott's poem The Lord of the Isles (4) |
| MCDONALD | One of the largest Scottish Highland clans, historically known as Lords of the Isles (8) |
| AFRICA | The second largest of the continents, after Asia (6) |
| MAUI | The second largest of the Hawaiian Islands |
| GUERNSEY | The second largest of the Channel Islands (8) |
