| GOZO | The second largest island in the Maltese archipelago (4) |
| SERB | Inhabitant of second largest island in the Mediterranean (4) |
| UIST | South ___ , second largest island in the Outer Hebrides (4) |
| MAUI | Second-largest island in the U.S. state of Hawaii (4) |
| SARDINIA | With the capital Cagliari, the second-largest island in the Mediterranean Sea (8) |
| MINDANAO | The second largest island in the Philippines (8) |
| PROP | The Maltese Falcon in "The Maltese Falcon," e.g. |
| NEWGUINEA | Divided between two countries, what is the second largest island in the world? (3,6) |
| HOY | The second largest island in Orkney, after Mainland |
| MULL | Second-largest island of the Inner Hebrides, on the Firth of Lorn (4) |
| SARD | Old name for an inhabitant of the Mediterranean's second largest island |
| HISPANIOLA | The most populated and second largest island in the Caribbean (10) |
| DISKO | Situated in Baffin Bay, the second-largest island of Greenland (5) |
| SKYE | Scotland's second largest island |
| COMINO | Island of the Maltese archipelago (6) |
| KODIAK | Second largest island in the United States, on the south coast of Alaska (6) |
| WAIHEKE | Second-largest island in the Hauraki Gulf (7) |
| EUBOEA | Second-largest island of Greece after Crete, in the western Aegean Sea (6) |
| VANUALEVU | Second-largest island of Fiji, formerly known as Sandalwood Island (5,4) |
| CHUKKAS | Periods of play in a game on horseback depicted by Rudyard Kipling in The Maltese Cat (7) |
