| MINNEAPOLIS | The largest city in Minnesota, located on the Mississippi River (11) |
| WOOLLENMILL | 19th-century textiles site in Almonte, an Ontario town on the Mississippi River: 2 wds. |
| HOOVERDATUM | "The first occupant of the White House to be born west of the Mississippi River," e.g.? |
| SPACENEEDLE | Iconic observational tower of Seattle which which was the tallest building west of the Mississippi River at the time it was built: 2 wds. |
| STLOUIS | Port on the Mississippi River; largest city in Missouri, US (2,5) |
| DULUTH | The fourth largest city in Minnesota, birthplace of Bob Dylan |
| HANNIBAL | City and port on the Mississippi River in Missouri, US; boyhood home of Mark Twain |
| BATONROUGE | State capital of Louisiana, in the SE on the Mississippi River (5,5) |
| MEMPHIS | A port in Tennessee on the Mississippi River; the site of Martin Luther King Jr's assassination (7) |
| ORLEANS | New _, port in Louisiana on the Mississippi River (7) |
| SAINTPAUL | State capital of Minnesota, on the Mississippi River (5,4) |
| STL | Missouri city on the Mississippi River: Abbr. |
| SAINTLOUIS | U.S. city, on the Mississippi River |
| OMAHA | City on the Mississippi River |
| NNE | Upstream on the Mississippi River, along Miss. |
| DELTA | Airline named for a region on the Mississippi river |
| IOWA | State on the Mississippi River |
| LSU | Sch. on the Mississippi River |
| STPAUL | Capital on the Mississippi River |
| BRAINERD | City in Minnesota |
