| BUTTERFLYEFFECT | The huge difference a comma can make? (9,6) |
| MACHISMO | Hi, commas can have exaggerated masculinity (8) |
| VISINE | "See the difference a little drop can make" sloganeer |
| DAYMAKES | Dinah Washington sang, "What a difference a ...; Twenty-four little hours; Brought the sun and the f |
| SWEEPINGCHANGES | The differences a broom can make? (8,7) |
| TIPPEDTHESCALES | Slight change made a big difference when Spooner skipped the tales (6,3,6) |
| TOUGHEN | Make it harder when there's a huge difference in weight (7) |
| MINIMUMWAG | The least a dog can make? |
| MALCOLM | ___ Gladwell, Canadian journalist and writer noted for his 2000 book The Tipping Point: How Little Things Can Make a Big Difference (7) |
| ATTITUDE | "A little thing that makes a big difference," per a popular saying |
| AVAST | There's a huge difference between it and "Full steam ahead!" (5) |
| OXFORD | A shoe, a shirt, a comma - or a city in England (6) |
| THERAPOD | The name of the most diverse group of saurischian ("lizard-hipped") dinosaurs, ranging from the crow-sized Microraptor to the huge Tyrannosaurus rex. |
| SPRING | Water makes a big difference to the garden! (6) |
| CHASM | Huge difference between viewpoints, say |
| CARGO | Shipment that chauffeur can make? |
| INSTANTMESS | What an exploding microwave can make? |
| ITD | "___ make a big difference!" |
| LAYARD | In 1849, this explorer returned to Mesopotamia and continued excavations at Nineveh and Babylon, discovering in the process the huge library of Ashurbanipal, probably the earliest library ever created |
| LARGE | REGAL EFFORT MAKES A BIG DIFFERENCE |
