| YMCA | The first US one opened in Boston in 1851 |
| KMART | The first one opened in Detroit in 1962 |
| LEGAL | Relating to the law in Boston in William Shatner series (5) |
| AEROSMITH | Rock band formed in Boston in 1970 whose hits include Love In An Elevator and I Don't Want To Miss A Thing (9) |
| ORR | Subject of a statue unveiled in Boston in 2010 |
| TONYDEMARCO | Former World Welterweight Champion boxer born Leonardo Liotta in Boston in 1932 |
| TEA | What went overboard in Boston in 1773 |
| IHOP | The first one opened near L.A. in 1958 |
| CLUBMED | The first one opened on Majorca in 1950 |
| THECARS | U.S. rock band formed in Boston in 1976 whose hits include You Might Think and Drive (3,4) |
| NBADYNASTY | Boston in the '60s or Chicago in the '90s, e.g. |
| PEPSI | What was the first US consumer product sold in the Soviet Union? (5) |
| HARRISON | William Henry _, the first US president to die in office, in 1841 (8) |
| WRANGLER | In the US, one is in charge of horses on a ranch (8) |
| JOHNGLENN | The first US astronaut to orbit the earth, in 1962, circling it thrice (4,5) |
| TYLER | In 1841, John ____ became the first US vice president to succeed to the presidency without election |
| BOBBYFISCHER | In 1972, who became the first US chess player to win the world championship? (5,7) |
| ANTON | Helen Hayes starred in the first US TV adaptation of ... Chekov's The Cherry Orchard |
| TEDDYROOSEVELT | Informally, the first US president to win the Nobel peace prize |
| SHEPARD | Alan, the first US astronaut to travel in space (7) |
