| JOHNGLENN | The first American astronaut to orbit the Earth (4,5) |
| GLENN | John ?, first American astronaut to orbit the earth |
| ALANSHEPARD | *First American astronaut to travel in space |
| ARMSTRONG | American astronaut who became the first person to walk on the Moon in 1969 (4,9) |
| JIMLOVELL | American astronaut who commanded the Apollo 13 lunar mission in 1970 (3,6) |
| SPUTNIK | Name for a series of space missions launched by the Soviet Union, the first of which launched the first man-made object to orbit the Earth |
| LAIKA | He was a stray dog picked off the streets of Moscow and the first animal to orbit the Earth in the Soviet spacecraft Sputnik 2 in 1957. |
| JOHN | Astronaut who became the first American to orbit the Earth in 1962 (4,5) |
| YURI | ___ Gagarin: the first man to orbit the earth? |
| DOG | What was the first animal to orbit the Earth? (3) |
| GGLLEENNNN | First American to orbit the Earth |
| TITOV | Gherman ___, cosmonaut who was the second human to orbit the earth |
| GAGARIN | First human to orbit the Earth |
| ENOS | Only ape to orbit the earth (1961) |
| NEIL | American astronaut who became the first person to walk on the Moon in 1969 (4,9) |
| CERNAN | Gene _, American astronaut; the last man to have walked on the Moon (6) |
| SPACEWALK | As per #26-Down... In 2001, Chris Hadfield became the first Canadian astronaut to perform this free-floating promenade way above the Earth |
| PEAKE | Author of a series of books set in the crumbling fictional castle Gormenghast; or, the first British ESA astronaut to visit the International Space Station (5) |
| TIMPEAKE | The first British astronaut to visit the International Space Station with the European Space Agency (3,5) |
| BUZZALDRIN | American astronaut who became the second person to set foot on the Moon in July 1969 (4,6) |
