| ECU | The brain of a modern motorcycle that can be programmed to modify how it performs. (3) |
| SIMCARD | Removable circuit board (standard, micro or nano) acting as the "brain" of a smartphone or mobile device (3,4) |
| MOPED | Light motorcycle that can be powered by pedals or an engine (5) |
| VCRS | They can be programmed |
| FOUR | Most popular number of cylinders, and strokes, in modern motorcycles. (4) |
| REDADMIRAL | Besotted lad married one with the brains of a butterfly |
| PACEMAKER | Device which may be programmed by a cardiac electrophysiologist |
| AMUSEMENTARCADE | Amateur needs Mac to be programmed for gaming site (9,6) |
| CPU | The brain of the computer |
| CAR | It performs best when tired? |
| VCR | Old device that was programmed to tape TV shows: Abbr. |
| CEREBRUM | The anterior portion of the brain of vertebrates, also called the telencephalon |
| ALPHAWAVE | Normal electrical impulse in the brain of someone awake and at rest, occurring at a frequency of 8 to 12 hertz (5,4) |
| UPSTAIRS | Puts on airs in a manner of speaking where the brains of the operation are (8) |
| ELECTRONICCONTROL | The 'brains' of racing machines when they started to interfere with a rider's input. (10,7,4) |
| UNIT | The 'brains' of racing machines when they started to interfere with a rider's input. (10,7,4) |
| THEMEANINGOFLIFE | What the computer Deep Thought was programmed to figure out in "The Hitchhiker's Guide to the Galaxy" |
| ROBOT | Any automated machine programmed to perform specific mechanical functions in the manner of a man (5) |
| DRUM | --- machine, a synthesizer programmed to reproduce the sound of percussion instruments in variable rhythms and combinations (4) |
| OCCURSTO | Reaches the brain of |
