| RIVERS | The Mississippi and the Ohio |
| DELTAS | The Mississippi and the Nile have them |
| WESTVIRGINIAN | Of a US state bounded by the Appalachians to the east and the Ohio River to the west (4,9) |
| STLOUIS | US city at the confluence of the Mississippi and Missouri rivers |
| HUCKS | Finn on the Mississippi, and others |
| IOWA | It's between the Mississippi and Missouri Rivers |
| ALLIGATOR | Genus of saurian reptile, common in the lower Mississippi and adjacent lakes and marshes (9) |
| STATES | Mississippi and Ohio |
| CAIRO | City on the Nile - or at the confluence of the Ohio and Mississippi rivers (5) |
| LOUISIANA | 'Pelican State' of the southern US, bordering Arkansas, Mississippi and Texas (9) |
| DEEP | Name for the states of Alabama, Georgia, Louisiana, Mississippi and South Carolina (4,5) |
| SOUTH | Name for the states of Alabama, Georgia, Louisiana, Mississippi and South Carolina (4,5) |
| CHICKASAW | A member of a Native American people who originally occupied lands in Mississippi and Alabama, and now live mainly in Oklahoma (9) |
| DEEPSOUTH | Collective name for the states of Alabama, Georgia, Louisiana, Mississippi and South Carolina (4,5) |
| LEE | County of Georgia, South Carolina, Mississippi, and Alabama |
| ALABAMA | State between Mississippi and Georgia |
| RICEBELT | Area including Arkansas, Louisiana, Mississippi and Texas |
| LAUDERDALE | County in Alabama, Mississippi, and Tennessee |
| ALA | Deep South state between Mississippi and Georgia: 2 wds. |
| SIOUX | Native American inhabiting upper Mississippi and Missouri valleys (5) |
