| ARTIFICIALHEART | The Jarvik was the first successful one |
| DARTSPLAYER | Was Cupid the first successful one? |
| ATRIA | What the Jarvik-7 attaches to |
| BIPLANE | Of which the Wright Flyer was the first successful powered example |
| ROALD | Leader of the first successful expedition to the South Pole, ... Amundsen |
| AMUNDSEN | Explorer who led the first successful expedition to the South Pole |
| JENNER | Edward ___, who devised the first successful vaccine and pioneered the science of immunology (6) |
| SALK | Jonas --, American virologist who developed one of the first successful polio vaccines (4) |
| BROWN | Sir Arthur Whitten -; the navigator of the first successful non-stop transatlantic flight (5) |
| JONASSALK | American medical researcher who developed one of the first successful polio vaccines (5,4) |
| IGORSIKORSKY | Designer of the first successful American helicopter, 1939 |
| REMINGTON | Company that launched (in 1874) the first successful typewriter (9) |
| SIKORSKY | Igor ---, Russian-American engineer who designed the first successful helicopter (8) |
| DUNLOP | Which Scottish inventor developed the first successful pneumatic bicycle tyre? (6) |
| FRANKWHITTLE | Creator of the first successful turbojet engine for airplanes (1937) |
| THIRDOFDECEMBER | 1967 date of the first successful heart transplant |
| GEORGESTEPHENSON | British inventor of the first successful steam locomotive |
| CONTACTLENSES | Vision-correcting devices about which Leonardo da Vinci, Rene Descartes and Sir John Herschel theorised before the first successful versions were made in 1888 (7,6) |
| WRIGHT | Surname of American brothers Orville and Wilbur, generally credited with inventing and building the first successful aeroplane (6) |
| NORGAY | Tenzing ___, Sherpa mountaineer who accompanied Sir Edmund Hillary on the first successful ascent of Mount Everest in 1953 (6) |
