| NAUGHTS | The 2000s, with "the" |
| SIMS | PC game sensation of the 2000s (with "The") |
| CRANFORD | Period drama of the 2000s with Judi Dench and Imelda Staunton (8) |
| ROME | Historical drama of the 2000s, with Kevin McKidd and Polly Walker (4) |
| INVICTA | Historic marque resurrected in the early 2000s with the S1 sports car (7) |
| PONY | Sketch show of the 1990s and 2000s with Sally Phillips, Smack The _ (4) |
| BARNEY | US children's show of the 1990s and 2000s with a purple dinosuar, _ & Friends (6) |
| THIS | British TV drama of the 1990s and 2000s with Andrew Lincoln, _ Life (4) |
| IGOTTAFEELING | 2009 Black Eyed Peas song that topped the charts for 14 weeks tied for the longest of the 2000s: 3 wds. |
| GEORGESTRAIT | I Cross My Heart country singer named the ACM Artist of the Decade for the 2000s: 2 wds. |
| ESURE | Company advertised by Michael Winner with the catchphrase Calm Down Dear in the 2000s (5) |
| LAGER | Drink that features in the title of the 2000s sitcom that featured the characters Gaz, Donna, Janet and Jonny (5) |
| GEE | Catherine - presenter on Escape To The Country in the 2000s and 60 Minute Makeover in the 2010s (3) |
| RANGE | Heidi ___, singer with the 2000s group Sugababes (5) |
| MOLE | With "The," 2000s reality show |
| SOPRANOS | With "The," 2000s drama featuring Uncle Junior, played by Dominic Chianese |
| ALEXRODRIGUEZ | Mariners/Rangers/Yankees slugger who hit the most home runs in the 2000s (435): 2 wds. |
| LLEYTONHEWITT | Best Australian player of the 2000s who never won the Australian Open |
| PONTING | Which batsman scored the most Test runs in the 2000s? |
| DAVIDGUETTA | I'm Good (Blue) French DJ with top 10 hits in the 2000s 2010s and 2020s: 2 wds. |
