| GAVIN | TV sitcom, - - - & Stacey |
| NED | Debra Messing and Thomas Haden Church starred in this sitcom (--- and Stacey) |
| ABSOLUTELY | TV sitcom and 2016 film that began 25 years ago this November (10,8) |
| FABULOUS | TV sitcom and 2016 film that began 25 years ago this November (10,8) |
| JOANNA | One of the stars of British TV sitcom and 2016 film that began 25 years ago this November |
| LUMLEY | One of the stars of British TV sitcom and 2016 film that began 25 years ago this November |
| NEST | Robin's ___, 1970s TV sitcom and spin-off of Man About The House (4) |
| GIMMEABREAK | 1980s Nell Carter sitcom, and a hint to the puzzle theme found in the ends of 17-, 32-, 39- and 46-A |
| IDEAL | British sitcom and cult hit created by Graham Duff and starring Johnny Vegas |
| OZZIE | 50s and 60s US sitcom, ... & Harriet (5) |
| THEGOLDENGIRLS | Sitcom and longer delights remade (3,6,5) |
| DHARMA | Jenna Elfman starred in this sitcom (------ and Greg) |
| DAVIDSPADE | Sitcom and former "SNL" star |
| LEE | C4 sitcom, --- and Dean (3) |
| DIFFRENTSTROKES | 1970s-'80s sitcom, and this puzzle's title |
| GRACE | Jane Fonda sitcom, ... And Frankie |
| PARKS | US sitcom, ----- and Recreation (5) |
| STEPTOE | Classic BBC sitcom, ------- and Son (7) |
| TWO | Jon Cryer sitcom: "- And A Half Men" |
| MORK | Old sitcom - and Mindy |
