| PARACELSUS | Swiss physician born Theophrastus von Hohenheim in 1493 |
| DAFFODIL | Birth flower for March such as the Narcissus poeticus identified in Theophrastus' Historic Plantarum, thought to be one of the first of its species to have been cultivated (8) |
| QUARTZ | Thought by Theophrastus to be a form of permanent ice, a silicious piezoelectric mineral such as the purple amethyst, smoky-brown cairngorm or the yellow citrine (6) |
| LAISABELA | Village in the Dominican Republic, founded by Christopher Columbus in 1493, considered the first formal European settlement in the New World |
| SYLPH | Spirit of the air, as originating in the system of Swiss physician and alchemist Paracelsus (c. 1493-1541) (5) |
| ALKAHEST | Hypothetical universal solvent sought by the alchemists, originating in the writings of the Swiss physician Paracelsus (1493-1541) (8) |
| ANTIGUA | Island Columbus reached in 1493 |
| STKITTS | Leeward Island visited by Columbus in 1493 |
| PINEAPPLE | What fruit did Columbus discover on Guadeloupe in 1493? (9) |
| JOHNSNOW | English physician born in 1813 noted for tracing a cholera outbreak in London (4,4) |
| GALEN | Roman physician born in the second century |
| ABSE | Dannie ___, Welsh poet and physician born in 1923 |
| SNOW | John, English physician born in 1813 noted for identifying cholera as a water-borne disease (4) |
| HIPPOCRATES | Physician born on the island of Kos |
| ERASTUS | Thomas --, Swiss physician and theologian (7) |
| MUESLI | Breakfast cereal developed around 1900 by Swiss physician Maximilian Bircher-Benner |
| ALCHEMIST | Swiss physician 'Paracelsus' was a famous 16th-century one (9) |
| SYLPHS | Spirits of the air, as conceived by the 16th-century Swiss physician Paracelsus (6) |
| STTHOMAS | Columbus discovery of 1493 |
| CADIZ | Spanish port from which Columbus sailed, 1493 |
