| ABRASIVES | Substances such as emery, sand or corundum used for smoothing or roughening surfaces |
| EMERY | Corundum used for grinding and polishing |
| AFROGINTHETHROAT | Temporary loss or roughening of the voice (1,4,2,3,6) |
| PUMICE | Stone used for smoothing or polishing (abl); met. of versus Propertius 3.1.8 |
| FILE | A tool for smoothing or shaping a hard material (4) |
| CULTUREMEDIA | Substances such as agar gel, as used in Petri dishes |
| MODELLER | One who makes figures or objects out of substances such as clay or wood (8) |
| SPIRITS | Alcohol denatured by the addition of poisonous substances such as methanol, used as a fuel, solvent etc. (10,7) |
| METHYLATED | Alcohol denatured by the addition of poisonous substances such as methanol, used as a fuel, solvent etc. (10,7) |
| PESTLE | Club-shaped implement used to grind substances such as garlic in a mortar. (6) |
| ACIDITY | Level of acid in substances such as water, soil or wine (7) |
| CONDIMENTS | Substances such as salt and mustard that are used to flavour food (10) |
| SNIFFERDOG | Canine trained to detect substances such as explosives or drugs (7,3) |
| ALKALINITY | Characteristic of substances such as lime or soda (10) |
| SPICES | Substances such as cumin, cloves, paprika, cinnamon, cardamom etc (6) |
| PRECIOUSMETALS | What are substances such as gold, silver and platinum? (8,6) |
| UMAMI | The taste of substances such as monosodium glutamate (5) |
| INERTGAS | Group of non-reactive substances such as neon and argon (5,3) |
| METALLURGY | The scientific study of the properties and uses of hard substances such as gold and iron (10) |
| ENZYMES | Substances such as amylase and pepsin |
