| BEESWAX | Substance from which honeycomb is constructed (7) |
| SUCHSWEETSORROW | What the beekeeper's parting with his honeycomb is? (4,5,6) |
| BAUXITE | A clay-like substance from which aluminium is obtained (7) |
| IRONORE | Substance from which the metal Fe is extracted (4,3) |
| ELEMENT | One of the essential substances from which heat is extracted (7) |
| ELMWOOD | Tree material low dome is constructed from (7) |
| MATERIAL | Substance from which something is made; cloth, fabric or textile; jokes, songs etc comprising a performer's act; or, the facts, ideas, notes etc collected as the basis of a book (8) |
| CORNET | Brass instrument whose name, from the Latin for "horn", refers to the substance from which it was originally made; or, a funnel-shaped thing, such as a cream horn or a gelato wafer (6) |
| YLEM | Substance from which the universe was created |
| LSD | Substance from which acid rock gets its name |
| GLASS | A barometer, beaker, goblet, lens, mirror, monocle, sand timer, telescope or watch face, each named for the vitreous crystal-like substance from which they are traditionally made (5) |
| VANILLA | What substance from a pod is a popular ice cream flavour? (7) |
| CAMPHOR | What substance from a tree wood is used in celluloid manufacture and as a cold treatment? (7) |
| LANOLIN | What substance from sheep is an ingredient in most chewing gums? (7) |
| QUININE | Medicinal substance from cinchona bark (7) |
| TREHALA | Edible sugary substance from cocoons of Asian beetles (7) |
| ANTIGEN | Get body substance from eating out before noon (7) |
| TAPIOCA | Substance from cassava used to thicken puddings (7) |
| ARSENIC | Hazardous substance from canister, unstable when temperature drops (7) |
| HORMONE | Natural substance from exotic moorhen (7) |
