| NASA | Space agency: abbr. |
| ISRO | Indian space agency preparing for the upcoming Proba-3 mission with the European Space Agency. (abbvr) (4) |
| ROSETTA | Space probe launched in 2004 by the European Space Agency (7) |
| TIMPEAKE | The first British astronaut to visit the International Space Station with the European Space Agency (3,5) |
| EUCLID | Space telescope launched by the European Space Agency in July 2023 to study dark matter and dark energy (6) |
| GIOTTO | First deep-space mission by the European Space Agency, launched to study the 1986 appearance of Halley's Comet (6) |
| ARIANE | European Space Agency launcher |
| NASAL | Space agency left whiny-sounding (5) |
| CSA | Space agency |
| NASDAQ | American space agency rings director with question to do with stock in securities (6) |
| HAPPYASASANDBOY | Content of hot download on phone? Space agency, perhaps, turning up alien body (5,2,1,7) |
| FRENCHGUIANA | Where does the European Space Agency carry out its launches? (6,6) |
| SATURN | Routine adopted by reduced space agency upheld type of rocket (6) |
| PEAKE | Tim ---, the first British citizen to be selected as an astronaut by the European Space Agency (5) |
| SPACELAB | Self-contained research laboratory developed by the European Space Agency (8) |
| NASARD | Stop space agency recall of Helen Sharman, for one? (6) |
| ISIRO | One employed by space agency at capital (5) |
| EISENHOWER | US president who created the space agency NASA (10) |
| ASIAN | American space agency returned, enheartened by one from the East (5) |
| NOTASAUSAGE | Space agency introducing cover for outermost custom zip (3,1,7) |
