| CRUX | Southern Cross constellation whose Jewel Box star cluster was named by Sir John Herschel (4) |
| PHOTO | Short word for an image taken with a camera whose full name was coined by Sir John Herschel in 1839 (5) |
| RUSTED | Tom cluster was impaired by neglect (6) |
| CHLORINE | Chemical element discovered by Carl Wilhelm Scheele in 1774 but named by Sir Humphry Davy in 1810 (8) |
| HELENSBURGH | Town on the north side of the Firth of Clyde in Scotland, named by Sir James Colquhoun after his wife (11) |
| SOAP | A painting by Sir John Everett Millais nicknamed "Bubbles" was used to advertise what product? (5,4) |
| BEES | Nickname of the public service broadcaster founded by Sir John Reith (4) |
| ARGO | Formerly a large constellation in the southern hemisphere between Canis Major and the Southern Cross. |
| TREK | Follow box star on foot (4) |
| VELA | Constellation near the Southern Cross |
| NEIL | Diamond in many a jewel box |
| DISC | Jewel box contents |
| SAFE | Jewel box? |
| RAS | Abbreviated name of the UK's learned society dedicated to solar-system science, conceived over dinner by Charles Babbage, Sir John Herschel and others in 1820 (1,1,1) |
| JEWEL | - Box; star cluster in Crux (5) |
| CONTACTLENSES | Vision-correcting devices about which Leonardo da Vinci, Rene Descartes and Sir John Herschel theorised before the first successful versions were made in 1888 (7,6) |
| PEARS | A painting by Sir John Everett Millais nicknamed "Bubbles" was used to advertise what product? (5,4) |
| TOMMYGUN | What weapon was named by its designer after John T Thompson, the American army officer who conceived the idea for it? (5,3) |
| COBALT | This metal was named by miners using the German word for 'goblin', because it was poisonous and degraded other elements such as nickel (6) |
| CHARLY | He was named by The Prodigy on their debut single (6) |
