| BUBO | Sign of the |
| AQUARIUS | In the rock musical Hair they sang of the dawning of the age of this watery sign of the zodiac |
| OCHIUCHUS | Located north-west of the Milky Way, the "serpent bearer" constellation known as the 13th sign of the zodiac (9) |
| WATSON | Dr -; fictional character in stories including A Study in Scarlet, The Sign of the Four and The Hound of the Baskervilles (6) |
| PHLOX | The acidity rate the pupil had was zero. Sign of the times for the flower (5) |
| CAPRICORN | The tenth sign of the zodiac, which the sun enters at the winter solstice |
| POISOND | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| SAGITTARIUS | Of the sign of the Archer (11) |
| LEONINE | One over the eight following the sign of the beast (7) |
| LIBRA | The seventh sign of the zodiac; or, the "Scales" constellation (5) |
| BARRETT | Wilson, English actor-manager who authored the play The Sign of the Cross (7) |
| AQUARIAN | According to the zodiac, a person born under the sign of the Water Bearer (8) |
| CANCER | In astrology, the fourth sign of the zodiac, also called the Crab (6) |
| DETROITLIONS | NFL team whose name includes the symbol of a sign of the zodiac (Leo): 2 wds. |
| MINNESOTATWINS | MLB team whose name includes the symbol of a sign of the zodiac (Gemini): 2 wds. |
| CHICAGOBULLS | NBA team whose name includes the symbol of a sign of the zodiac (Taurus): 2 wds. |
| TAURUS | The second sign of the zodiac, also called the Bull (6) |
| RUT | Tom initially returns to the old city sign of the passage of vehicle... (3) |
| ARIES | The first sign of the zodiac, ruled by the planet Mars (5) |
| GEMINI | The "Twins" constellation; or, the third sign of the zodiac (6) |
