| PUDDYTAT | Sighting in a classic Looney Tunes cartoon |
| SCARLET | With "The" and 45-Across, classic Looney Tunes cartoon that's a parody of a classic novel |
| NOVA | Sighting in a telescope |
| ROADRUNNER | N. American ground bird, portrayed in a Looney Tunes cartoon series (10) |
| DAFFY | Looney Tunes cartoon character with a short fuse, ----- Duck (5) |
| PEW | Pepe Le-, name of a Looney Tunes cartoon character (3) |
| WHATSUPDOC | Classic Looney Tunes tagline offering some "direction" in solving the starred clues |
| OPERA | "What's __, Doc?": Classic "Looney Tunes" short |
| COYOTE | Wile E. _ _ _ _ _ _, antagonist of the Road Runner in the Looney Tunes cartoon (6) |
| ACME | Word from the Greek for "highest point" that was adopted by Warner Bros as the name of a corporation in Looney Tunes cartoons (4) |
| THATSALLFOLKS | "Looney Tunes" cartoon sign-off line (5,3,5) |
| LEGHORN | Looney Tunes cartoon rooster, Foghorn ... (7) |
| PORKYPIG | Stuttering Looney Tunes cartoon character (5,3) |
| ELMER | Looney Tunes cartoon character, ... Fudd |
| BUNNY | "Mutiny on the ___" (Looney Tunes cartoon) |
| SPEEDY | _ Gonzales, Looney Tunes cartoon mouse (6) |
| FRIZ | "Looney Tunes" cartoon director Freleng |
| PORKY | Pig in Looney Tunes cartoons |
| HEN | Type of animal Miss Prissy is in Looney Tunes cartoons |
| TAZ | Devil in Looney Tunes cartoons, informally |
