| HILARY | She played the title role in Lizzie Maguire, _ Duff (6) |
| SPIDER | Movie hero once played by Tobey Maguire, _-Man (6) |
| CUBA | Actor who delivers the line "Show me the money" in Jerry Maguire, ___ Gooding Jr. |
| ROONEY | She played The Girl with the Dragon Tattoo in the 2011 US version (6,4) |
| BLYTHE | Scottish actress who played Jackie Reid in Taggart, _ Duff (6) |
| DUFF | Hilary _, US actress who played the title role in Lizzie McGuire (4) |
| NICOLEKIDMAN | She played the title role of a U.N. employee in the 2005 thriller The Interpreter, director Sydney Pollack's last film |
| SHERIDANSMITH | She played the title role in the 2014 drama Cilla about the early career of Cilla Black (8,5) |
| ANNJILLIAN | She played the title role in the 1982 TV movie "Mae West" |
| LINDALAVIN | She played the title role in the sitcom "Alice" |
| SEEMABISWAS | She played the title role in Shekhar Kapoor's Bandit Queen (5,6) |
| ANDREAMCARDLE | She played the title role in the original Broadway production of "Annie" |
| AALIYAH | She played the title character in "Queen of the Damned" |
| SALLY | She played the title role in 1979's Norma Rae |
| FIELD | She played the title role in 1979's Norma Rae |
| JULIANNEMOORE | She played the title role in 2019's Gloria Bell |
| SURANNEJONES | She played the title role in Gentleman Jack (7,5) |
| AMERICA | She played the title role in Ugly Betty, _ Ferrera (7) |
| SANDRAOH | She played the title role in Killing Eve |
| RENEE | She played the title role of Bridget in 2001, '04, and '16 |
