| DISKO | Second-largest island of Greenland after the mainland, also known as Qeqertarsuaq (5) |
| DANGERLINE | It's perilous to cross immoral leader invested in Greenland after meltdown (6,4) |
| ISLEOFPINES | The second-largest Cuban island after the mainland, what was the former name of Isla de la Juventud? (4,2,5) |
| UNST | Third largest of the Shetland Islands after the Mainland and Yell (4) |
| OLAND | Second-largest island of Sweden, separated from the mainland by Kalmar Sound (5) |
| SERBS | Inhabitants of the Mediterranean's second-largest island (5) |
| MINDANAO | Second-largest island of the Philippines, known as the Land of Promise (8) |
| VANUALEVU | Second-largest island of Fiji, formerly known as Sandalwood Island (5,4) |
| MULL | Second-largest island of the Inner Hebrides, on the Firth of Lorn (4) |
| MAUI | Second-largest island of Hawaii, known as the Valley Isle (4) |
| EUBOEA | Second-largest island of Greece after Crete, in the western Aegean Sea (6) |
| HOY | Second largest island of the Orkney archipelago |
| HOKKAIDO | Second largest island of Japan (8) |
| SARDINIA | With the capital Cagliari and situated directly south of Corsica, the second-largest island in the Mediterranean Sea, site of Costa Smeralda (8) |
| KODIAK | Second largest island in the United States, on the south coast of Alaska (6) |
| PAPUANEWGUINEA | Eastern half of the world's second largest island (5,3,6) |
| NEWGUINEA | After Greenland, the world's second-largest island |
| SERB | Inhabitant of second largest island in the Mediterranean (4) |
| SARD | Old name for an inhabitant of the Mediterranean's second largest island |
| GOZO | The second largest island in the Maltese archipelago (4) |
