| KANDAHAR | Second largest city of Afghanistan |
| KABUL | The capital and largest city of Afghanistan (5) |
| HERAT | City of Afghanistan |
| SALTO | Second-largest city of Uruguay, on the east bank of the Uruguay River opposite the Argentine city of Concordia (5) |
| MARACAIBO | Second-largest city of Venezuela; capital of the state of Zulia (9) |
| CEDARRAPIDS | Second-largest city of the state of Iowa; birthplace of celebrities including Ashton Kutcher and Elijah Wood (5,6) |
| NOVISAD | Second-largest city of Serbia; capital of the autonomous province of Vojvodina (4,3) |
| GRAZ | Second-largest city of Austria by area; capital of the state of Styria (4) |
| MANDALAY | Second-largest city of Myanmar, on the east bank of the Irrawaddy River north of Yangon (8) |
| LAHORE | Second-largest city of Pakistan; capital of the north-eastern Punjab province (6) |
| ESPOO | Second-largest city of Finland, in the south just west of Helsinki (5) |
| JODHPUR | Second-largest city of the Indian state of Rajasthan, founded by the military Chieftain Rao Jodha in 1459 (7) |
| MOMBASA | Second-largest city of Kenya; capital of the British East Africa Protectorate until 1907 (7) |
| PLOVDIV | Second-largest city of Bulgaria; as Trimontium, the capital of Roman Thrace (7) |
| BRNO | Second-largest city of the Czech Republic, in the SE at the confluence of the Svitava and Svratka rivers (4) |
| TUCSON | Second-largest city of the US state of Arizona, known as 'the Old Pueblo' (6) |
| ESSEN | German city which is the second-largest city of the Ruhr (5) |
| POINTENOIRE | Chief port and second-largest city of the Republic of the Congo, named from peninsular black rock observed by Portuguese navigators (6,5) |
| MONTREAL | Second-largest city of Canada (8) |
| LODZ | Second largest city of Poland (4) |
