| MUNGOPARK | Scottish explorer who followed the course of the Niger River (5,4) |
| PARK | Mungo, Scottish explorer who led two expeditions to trace the course of the Niger (4) |
| TRACED | Followed the course of |
| ONITSHA | Port city on the eastern bank of the Niger river in Anambra State, Nigeria |
| TIMBUKTU | City in Mali about 15 km north of the Niger River |
| PROGNOSIS | Poor signs of obtaining a likely forecast of the course of the disease (9) |
| NAVIGATOR | Member of crew who is responsible for the course of the vessel (9) |
| OILRIVERS | The delta of the Niger, in Nigeria (3,6) |
| HELLEBORE | The 'niger' species of this plant is often called 'Christmas Rose' (9) |
| NIAMEY | Capital of Niger on the Niger River (6) |
| RACE | The channel of a millstream, the course of the sun or moon; or, the rapid current or flow of the tides (4) |
| MUNGO | ___ Park, 1771-1806, Scottish surgeon and explorer who went to Africa to discover the course of the River Niger (5) |
| BOZO | Ethnic group of Mali located along the Niger River (4) |
| CORI | First woman to be awarded the Nobel Prize in Physiology or Medicine for her role in the discovery of the course of the catalytic conversion of glycogen (surname only) |
| GHANA | Modern African state; also a medieval empire situated between the Sahara and the Niger river (5) |
| SYRIA | Country containing about 440 miles of the course of the Euphrates and about 27 miles of the Tigris |
| ROUSSEAU | Genevan 'philosophe' who influenced the course of the Age of Enlightenment |
| RAE | John ___, 19th-century Scottish explorer who authored the book Narrative of an Expedition to the Shores of the Arctic Sea, in 1846 and 1847 (3) |
| MALI | The Niger River flows through it |
| BANTU | Number of African languages that comprise a sub-branch of the Niger-Congo languages (5) |
