| SEABORN | Sam __, character played by Rob Lowe in The West Wing (7) |
| SODAPOP | "The Outsiders" role played by Rob Lowe |
| MALONE | Sam ___, character played by Ted Danson in the sitcom Cheers (6) |
| SAMSEABORN | The West Wing's deputy communications director, played by Rob Lowe (3,7) |
| YAHTZEE | Dice game patented by Edwin S Lowe in 1956 (7) |
| JEFFREY | Actor who portrays Bernard Lowe in Westworld, - Wright (7) |
| PETSHOP | _ _ Boys, musical duo formed by Chris Tennant and Chris Lowe in 1981 (3,4) |
| BRYN | Uncle ___, character played by Rob Brydon in the TV sitcom Gavin & Stacey (4) |
| GRINDER | Rob Lowe thought he was a lawyer in this (The -------) |
| WEST | Bryn, character played by Rob Brydon in Gavin & Stacey (4) |
| STELMOS | Demi Moore and Rob Lowe romantic drama, ___ Fire |
| DIGBY | Arthur __, Holby City medic played by Rob Ostlere (5) |
| DEUCEBIGALOW | Male gigolo played by Rob Schneider |
| JOHN | Holiday in the Wild actor who is also the son of actor Rob Lowe |
| SAM | Rob Lowe's role on "The West Wing" |
| ROBIN | Mr Lowe in Songbird (5) |
| BRATPACK | Rob Lowe was in this set of actors in 1980s coming-of-age films (4,4) |
| CELEBSGO | Words that when followed by Dating gives the title of an E4 show narrated by Rob Beckett (6,2) |
| ALL | Word that when followed by Together Now gives the title of a 2010s show presented by Rob Beckett and Geri Horner (3) |
| SHIA | LaBeouf parodied as a cannibal in a music video by Rob Cantor |
