| NAYLOR | Ruthless Holby City Hospital consultant with a brain tumour (3,6) |
| JAC | Ruthless Holby City Hospital consultant with a brain tumour (3,6) |
| RIC | ___ Griffin, long-serving Holby City Hospital consultant general surgeon (3) |
| PHYSICIAN | Is leading consultant with any hip problem, perhaps? |
| DAVIDBALDACCI | Author of the Amos Decker crime novels about an FBI consultant with perfect recall: 2 wds. |
| TALC | Chalky stuff used by hospital consultants (4) |
| LEXI | Albert Square kid who learned her mum has a brain tumour (4) |
| PEARCE | Albert Square kid who learned her mum has a brain tumour (6) |
| SEVEBALLESTEROS | Three-time British Open golf champion who died of a brain tumour in 2011 (4,11) |
| REGISTRAR | Raf di Lucca works at Holby City Hospital as a specialist emergency medicine __ (9) |
| MOEFFANGA | Transplant co-ordinator at Holby City Hospital (2,7) |
| JASONDURR | Actor who plays Holby City Hospital ED staff nurse David Hide (5,4) |
| EMERGENCY | ___ department, location that Casualty is set within Holby City Hospital (9) |
| SACHALEVY | He left Holby City Hospital after being framed by Dom Copeland (5,4) |
| WILLNOBLE | New paediatric registrar in the Holby City Hospital emergency department, played by actor Jack Nolan (4,5) |
| TARA | __ Lo, late Holby City medic who didn't survive surgery on her brain tumour (4) |
| INTACT | "I'm one of those rare breed of rock 'n' rollers with a brain, probably because the brain's still ___:" Suzi Quatro (6) |
| MENSA | Org. with a Brain Training app |
| MOIRA | Farmer in Emmerdale who went under the knife to have her brain tumour operated on (5,6) |
| DINGLE | Farmer in Emmerdale who went under the knife to have her brain tumour operated on (5,6) |