| LLAMA | Ruminant mammal of the family Camelidae native to the Andes, valued as a beast of burden and a source of wool (5) |
| PACKANIMAL | Beast of burden, and a hint to 17-, 25-, 36- and 49-Across |
| ADDLE | Remove top of burden and go off (5) |
| CROSSSTITCH | The embroidery could be a burden and a pain (5-6) |
| SADDLESTITCH | Some sewing - burden and a pain (6,6) |
| GUANACO | Wild South American mammal of the family Camelidae of which the llama is a domesticated descendant (7) |
| ALPACA | South American mammal of the family Camelidae that is the domesticated descendant of the vicuna (6) |
| CETUS | Which constellation is represented in Greek mythology as a beast of the sea, often thought of as a w |
| CAMEL | Animal of Asia and Africa, used for riding and as a beast of burden (5) |
| SIKA | and 3dn, Mammal of the family Cervidae native to Japan, Russia and China with a short head and compact body |
| SIKADEER | and 3dn, Mammal of the family Cervidae native to Japan, Russia and China with a short head and compact body |
| BACTRIAN | Animal used as a beast of burden in the cold deserts of central Asia (8.5) |
| DEER | Mammal of the family Cervidae native to Japan, Russia and China with a short head and compact body (4,4) |
| QUINOA | Plant in the amaranth family, native to the Andes and widely cultivated (6) |
| CERVID | Any ruminant mammal of the deer family, in the order Artiodactyla (6) |
| OKAPI | Ruminant mammal of the forests of Central Africa with a reddish-brown coat (5) |
| GENET | Cat-like nocturnal mammal of the family Viverridae closely related to the civet, having spotted fur and a long ringed tail (5) |
| TAKEITONTHELAMB | Use a young sheep as a beast of burden? |
| PIKA | Any burrowing lagomorph mammal of the family Ochotonidae of Asia and North America, also called cony and mouse hare (4) |
| GUINEAPIG | ... It's a rodent native to the Andes |
