| BRIDPORT | Resort town in West Dorset east of Lyme Regis (8) |
| WORTHING | Resort town in West Sussex just west of Brighton (8) |
| JURASSIC | Term applied to fossil-rich area of Dorset / East Devon coasts (8) |
| AMMONITE | Fossilised spiral shell of an extinct mollusc common in Lyme Regis or Charmouth (8) |
| GLANDERS | Waterfowl catching onset of Lyme disease |
| MERE | Water in harbour of Lyme Regis |
| LYM | River of Lyme Regis - in Plynlimon! (3) |
| FOSSIL | Meaning 'to dig', the petrified remains of a prehistoric creature or plant, such as an ammonite of Lyme Bay, Dorset or a St Hilda's snakestone of Whitby, Yorkshire |
| DISEASES | Afflictions such as Weil's and Lyme (8) |
| ANNING | Mary_, highly regarded fossil hunter of the 19th century, who was born and died in Lyme Regis, Dorset (6) |
| COBB | Swan, black, a feature of Lyme |
| TICK | Small arachnid responsible for the spread of Lyme Disease (4) |
| ORANGERY | A sheltered place or greenhouse for growing citrus trees; there is a particularly fine example at Lyme Park, a National Trust house near Macclesfield (8) |
| DELABECHE | Englishman whose years in Lyme Regis and acquaintance with fossil collector Mary Anning inspired his palaeontological interest and subsequent founding of the world's first geological survey (2,2,5) |
| DORSET | Lyme Regis is in this county (6) |
| AUSTEN | Author whose novel Persuasion is partly set in Lyme Regis (6) |
| POLYMER | Macromolecular substance found in Aleppo, Lyme Regis (7) |
| MERELY | Only US soldiers leaving Lyme Regis in trouble (6) |
| REGIMES | Transformed Lyme Regis, giving up half of July to develop systems (7) |
| DEER | Carriers of Lyme ticks |
