| AMERICAS | Region of the world |
| THULE | Northernmost region of the world, according to the ancients |
| MIDDLEEAST | Region of the world that includes the Arabian Peninsula (6,4) |
| SATELLITE | Device used to capture images of various regions of the world from the International Space Station. (9) |
| ASIA | ___-Pacific (Region of the World) |
| BIOME | British writer touring island and old region of the world (5) |
| BLUEZONE | A term for a region of the world in which people tend to live longer (4,4) |
| ABDOMEN | The region of the body of a vertebrate containing the stomach and intestines (7) |
| MISSOURI | State in the Midwest region of the US that was the birthplace of Mark Twain |
| NEWGEORGIA | Island in the western region of the Pacific nation of the Solomon Islands (3,7) |
| TOMME | Variety of cheese made in the Savoy region of the Swiss Alps, traditionally on the same farm from which its milk is sourced (5) |
| NEWENGLAND | NE region of the US and focus of the War of Independence (3,7) |
| MENSA | A faint constellation in the polar region of the southern hemisphere and containing part of the Large Magellanic Cloud. |
| MACEDONIA | Geographical and historical region of the Balkan peninsula considered to include parts of six countries, including Greece, Bulgaria, Albania and parts of the former Yugoslavia |
| OORT | Dutch astronomer who first postulated the existence of a cloud in the most distant region of the solar system where long-period comets are thought to originate (4) |
| SULUSEA | Region of the western North Pacific between northeastern Borneo and the southwestern islands of the Philippines (4,3) |
| KUIPER | A region of the solar system beyond the orbit of Neptune, consisting of icy debris (6,4) |
| BELT | A region of the solar system beyond the orbit of Neptune, consisting of icy debris (6,4) |
| SIDE | Either of the two faces of a vinyl record; or, a region of the body between armpit and hip (4) |
| CANALZONE | Former administrative region of the U.S. on the Isthmus of Panama (5,4) |
