| LOLED | Reacted to a meme, informally |
| CATS | Pets that, according to a meme, can have a little salami as a treat |
| LOL | Reaction to a meme, maybe |
| LAUGH | Reaction to a meme, maybe |
| LOLS | Reacts to a meme, maybe |
| LOLING | Reacting to a meme, maybe |
| DARKESTTIMELINE | Worst possible existence, in a meme, and a hint to six squares in this puzzle |
| HONORING | "How to Wear Makeup in a God ___ Way" (Christian lifestyle video whose title became a meme) |
| WIRED | Rhyming alternative to "tired," in a meme |
| DOGE | Lead-in to "coin" for a meme currency |
| EMMA | A meme mostly about a novel (4) |
| ORB | Round object "pondered" by a wizard, in a meme |
| ORLY | Paris airport, or letters on a picture of an owl in a meme |
| CAT | Animal sitting behind a plate of salad, in a meme |
| RELATABLE | Like a post from a meme account that you'd share on your Insta Story |
| LOOKALIKE | Owen Wilson vis-a-vis the Statue of Liberty, in a meme |
| ELMO | Muppet standing in front of a fire, in a meme |
| ITYOU | Text from a friend who just sent a meme capturing your personality |
| HER | "GET A JOB" and "STAY AWAY FROM ___" (Instagram comments made by Demi Lovato that became a meme) |
| FLORIDAMAN | Headline starter that became a meme about a person caught in bizarre acts |
