| EXPRESSWAYS | Put into words means for major routes in the US (11) |
| WATERWAY | E.g. one of many wet routes in the Fens (8) |
| MALARIA | In Italian, this word (actually, two words) means "bad air." In English, it refers a human disease caused by parasites of the genus Plasmodium transmitted by mosquitos. Its first known use was in 1740 |
| RHODES | Mentioned routes in the Aegean |
| ENVOI | Writer's last words means violin occasionally (5) |
| SEMANTIC | Holding a book, half-clear at first about what words mean |
| TREESURGEON | Who might improve avenues, getting green routes in order |
| INTERSTATES | Major routes |
| BRENNERPASS | Low- lying route in the Alps connecting Innsbruck, Austria, with Bolzano, Italy (7,4) |
| SUBSTANDARD | This word means inferior (11) |
| MIGRATED | Major route in shreds, moved away (8) |
| STYMIE | Obstruct major route in Sweden yet to be built (6) |
| EXAMINE | Survey times on a major route in east and northeast (7) |
| AROAD | Major route in foreign parts avoided by British |
| MOTORWAY | Major route in Britain |
| ARTERIAL | Hesitation in a complex trial of major routes (8) |
| ARTERY | Word for a blood vessel, such as the aorta, thus for a major route or road in any complex system (6) |
| EMIR | Major route is put in here essentially for Arab chieftain (4) |
| TEMPO | This word means in Italian "rate of speed," in reference to music. The Italian, in turn, is derived from a Latin word meaning "time." The first known use is c. 1724. |
| BILSTON | Town on the Black Country Route in the West Midlands south-east of Wolverhampton (7) |
