| IKEA | Producer of the world's most widely |
| ANNEFRANK | Diarist, born 1929, who wrote one of the world's most widely known books (4,5) |
| SCOTS | - pine; national tree of the country with the capital Edinburgh; the world's most widely distributed conifer (5) |
| CAFFEINE | The world's most widely consumed psychoactive drug |
| GARFIELD | What is the world's most widely syndicated cartoon strip? (8) |
| ARABICA | What is the world's most widely grown coffee bean? (7) |
| OKAY | Word which has been described as the world's most widely understood (4) |
| ESPERANTO | The world's most widely spoken artificial language, devised in 1887 (9) |
| CNN | World's most widely distributed syndicated news service |
| POTATO | World's most widely grown tuber crop |
| LEOPARD | World's most widely distributed big cat |
| ASSOCIATIONFOOTBALL | World's most widely played and watched team sport (11,8) |
| ODEON | - of Herodes Atticus; 1,858-year-old amphitheatre on the south slope of the Acropolis where some of the world's most revered opera singers have performed (5) |
| NEWTON | Scientist whose magnum opus Principia was published by the Royal Society with the help of Edmond Halley in 1687 and remains one of the world's most influential works |
| THELASTSUPPER | Painting created at the end of the 15th Century, one of the world's most recognisable artworks (3,4,6) |
| GREATWALL | Series of fortifications in China, along part of which one of the world's most challenging marathons |
| MACAW | Scarlet -; parrot of the Amazon; one of the world's most colourful birds (5) |
| EIGER | Mountain of the Bernese Alps whose North Wall, or "Nordwand", is one of the world's most difficult ascents (5) |
| ETNA | One of the world's most active volcanoes, in a state of eruption for much of 2021 (4) |
| IBSEN | Norwegian author of A Doll's House, one of the world's most performed plays. (5) |
