| ORGANIC | Produced without synthetic chemicals |
| DESIGNERDRUG | Having synthetic chemical, mean to process red carpet |
| DUBNIUM | Synthetic chemical element; symbol Db |
| BOHRIUM | Synthetic chemical element with the atomic number 107 |
| OGANESSON | Synthetic chemical element with the highest atomic number (118), formally named on November 28 2016 (9) |
| NOBELIUM | Synthetic chemical element with the atomic number 102 (8) |
| ALE | Formerly, a drink like beer produced without hops |
| NIECE | Relative's new composition produced without pressure |
| IMMEDIATE | Item I made can be produced without delay |
| ORGANICCOFFEE | Brew produced without pesticides |
| TELEKINESIS | Motion produced without material force |
| BEAUTIFUL | Stunning bluefin tuna produced without any nitrogen (9) |
| INHOUSE | Produced without the need for outsourcing (2-5) |
| BORON | Element briefly found in two bits of 16 part 1 produced without love (5) |
| IKNEWIT | ? White ink produced without hydrogen. Told you! (1,4,2) |
| INDIEMUSIC | Genre of rock, pop etc produced without a mainstream record label (5,5) |
| EASILYDONE | Far and Away, The Godfather and X-Men - the third produced without much difficulty (6,4) |
| GROSS | Sensual sort of orgasms produced without a male present (5) |
| GRATIS | First of adventurers tucking into grits produced without charge (6) |
| SONORANT | In phonetics, a frictionless speech sound (l, r, m etc.) produced without turbulent airflow in the vocal tract (8) |
